Page 37 - CIBER-BBN2016-ENG

• Vectorized multicomponent nanoparticles as drug delivery systems and modulators of pharmacokinetic properties.
• Multimodal imaging agents (SPECT, OI, CT and MRI). Nanoparticles for imaging diagnostic applications.
• Surface engineering for controlling cell proliferation on diverse materials.
• Development of solid phase methodology to synthesize biomolecules and other compounds.
• Bionanotechnologies as new strategy to save compounds that failed on clinical or preclinical phases.
Most relevant scientific articles
• Mendive-Tapia L., Zhao C., Akram A.R., Preciado S., Albericio F., Lee M. et al. Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue. Nature Communications. 2016;7.
• Pelay-Gimeno M., Albericio F., Tulla-Puche J. Synthesis of complex head-to-side-chain cyclodepsipeptides. Nature Protocols. 2016;11(10):1924-1947.
• Giannotti M.I., Abasolo I., Oliva M., Andrade F., García-Aranda N., Melgarejo M. et al. Highly Versatile Polyelectrolyte Complexes for Improving the Enzyme Replacement Therapy of Lysosomal Storage Disorders. ACS Applied Materials and Interfaces. 2016;8(39):25741-25752.
• Paradis-Bas M., Tulla-Puche J., Albericio F. The road to the synthesis of “difficult peptides”. Chemical Society Reviews. 2016;45(3):631-654.
• Mendive-Tapia L., Bertrán A., García J., Acosta G., Albericio F., Lavilla R. Constrained Cyclopeptides: Biaryl Formation through Pd-Catalyzed C−H Activation in Peptides—Structural Control of the Cyclization vs. Cyclodimerization Outcome. Chemistry - A European Journal. 2016;22(37):13114-13119.
Highlights
In 2016 our group has initiated a 4 years’ project “Preparación facilitada de compuestos químicos relevantes en biología”, granted by MINECO (CTQ2015-6787OP). The main goal of this project is developing new synthetic methods to obtain diverse type of molecules with relevant biological activity, as antitumoral drugs, or fluorescent label molecules with application to diagnostic by imaging. Furthermore, during this year the group has continued working on the projects CHEMTOOLBOX (MINECO, SAF2014-60138-R), PENTRI (FUNDACIÓ MARATÓ TV3, TV32013-133932), TERARMET (MINECO, RTC-2014-2207-1) and the transfer technology project LIPOCEL (CIBER-BBN). The two first projects (CHEMTOOLBOX and PENTRI) are devoted to the development of drug delivery systems for advanced colorectal and triple negative breast cancer treatment, and peptide transporters. The other two, TERARMET and LIPOCEL projects are focused on the development of a protein delivery system for enzyme replacement treatment for Fabry and San Filippo diseases. During this year, the results generated for these two projects facilitated the presentation of a european project in coordination with other CIBER-BBN groups that have been granted (SMART-4-FABRY) and initiated in 2017. This project has the objective to approach the enzyme delivery system developed in collaboration with other CIBER-BBN groups to clinical phases.
During this year, the group has continued working collaborative projects with private companies (Almirall, Servier, Landsteiner Genmed and Biokit).
BBN
Research Groups 37