Page 69 - CIBER-BBN2016-ENG

- DALI Project: Lifestyle intervention in the prevention of Gestational Diabetes (GDM). It is a EU Research Project (7th Framework).
- Telemedicine and Intelligent Systems for Therapeutic Optimization of Diabetes Mellitus. Investigation of combined open and closed loop systems to achieved normoglycemia in type 1 diabetes.
• DM-2, Obesity, Metabolic Syndrome, Hyperlipidemia, Cardiovascular Risk.
- We investigate the role of vitamin D in the prevention of DM and the MS (one PhD Thesis already ended in 2013).
• Endocrinology of Reproduction (Diabetes and Thyroid).
- Monogenic diabetes and pregnancy. Investigation of the prevalence of MODY-2 and 3, as well as fetomaternal morbidities.
- Gestation and Diabetes. Research activities involving macrosomia, influences of race, and adaptative changes of therapeutic insulin regimens.
Most relevant scientific articles
• Harreiter J., Simmons D., Desoye G., Corcoy R., Adelantado J.M., Devlieger R. et al. IADPSG and WHO 2013 gestational diabetes mellitus criteria identify obese women with marked insulin resistance in early pregnancy. Diabetes Care. 2016;39(7):e90-e92.
• Feig D.S., Asztalos E., Corcoy R., De Leiva A., Donovan L., Hod M. et al. CONCEPTT: Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial: A multi-center, multi-national, randomized controlled trial - Study protocol. BMC Pregnancy and Childbirth. 2016;16(1).
• Benhalima K., Mathieu C., Damm P., Van Assche A., Devlieger R., Desoye G. et al. Erratum to: A proposal for the use of uniform diagnostic criteria for gestational diabetes in Europe: an opinion paper by the European Board & College of Obstetrics and Gynaecology (EBCOG) (Diabetologia, 10.1007/s00125-015-3615-7). Diabetologia. 2016;59(8):1791.
• Caimari F., Valassi E., Garbayo P., Steffensen C., Santos A., Corcoy R. et al. Cushing’s syndrome and pregnancy outcomes: a systematic review of published cases. Endocrine. 2016;:1-9.
• García-Patterson A., Minambres I., Adelantado J.M., Gich I., Puig T., de Leiva A. et al. Sex ratio at birth is associated with type 1 diabetes characteristics. Acta Diabetologica. 2016;:1-11.
Highlights
• Main results of research activities: Pregnant women with a BMI > 29 underwent a 75 g-OGTT in early pregnancy. GDM depicted greater insulin resistance, BMI, waist circumference, blood pressure, triglycerides, free fatty acids, 3-beta-hydroxybutirate, and heart rate at screening. Prepregnancy BMI was a significant predictor of early GDM. (EU Project DALI. Diabetes Care 2016;39:e90-e92).
We investigated the association between maternal diabetes and sex ratio at birth (SRB) in women with DM-1. SRB was significantly associated with 3 diabetes characteristics: diabetes duration, first-trimester HbA1c,
and insulin dose. (Acta Diabetol (DOI 10.1007/s00592-016-09-0). This study (CONCEPTT Study Protocol, sponsored by JDRFI) investigates whether the use of real-time continuous glucose monitoring (RT-CGM) will improve glycemic control in women with type 1 diabetes who are pregnant (214) or planning pregnancy (110). (ClinicalTrials.gov identifier: NCT01788527). The primary outcome is the change in HbA1c. Secondary outcomes include maternal hypoglycemia, CGM time-in, above and below target, glucose variability, maternal and neonatal outcomes. (BMC Pregnancy and Childbirth 2016: 167-175).
• Doctoral Thesis: Silent Atherosclerosis in type 1 diabetes. This research demonstrated the importance of glycemic control in patients with DM-1 prospectively followed from the onset during more than 20 years. This proposal was quite confirmed within the early phase of the disease (metabolic imprinting). 33% of patients developed subclinical atherosclerosis and qualitative alterations of HDL related to phospholipase A2. An excess of epicardial fat identified patients with severe cardiometabolic risk. (PhD Candidate, Cristina Colom. Thesis Directors, A. de Leiva and A. Chico, UAB-2016-cum laude).
Research Groups 69
• Textbook of Diabetes and Pregnancy. M. Hod, L. Jovanovic, GD Di Renzo, A. de Leiva and O. Langer have coedited a textbook written by a cadre of international experts. A comprehensive review, with new chapters devoted to obesity, bariatric surgery and epidemiology. A key reference for maternal-fetal medicine specialists and diabetologists. (CRC Press-2016).
BBN