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leaD reSearcher
Leiva Hidalgo, Alberto
Instituto de Investigación del Hospital de la Santa Creu i Sant Pau
S Antoni Ma Claret 167
pab. Sant Frederic, pl. 1 08025 Barcelona
(+34) 93 553 78 95 [email protected] group Website
GROUP MEMBERS
Staff members: Blanco Soto, Rosa María | Mato Matute, Ma Eugenia Associated members: Chico Ballestero, Ana Isabel | Corcoy Pla, Rosa Contributors: Cubero Marcos, José María | González Blanco, Cintia
Main lines of research
THYROID CANCER
• Markers of prognostic prediction.
- Implication of 21 genes in CDT. Development of data base, and a private collection of serum and tissue bank of epithelial thyroid cancer (more of 200 cases). We found he relationship between the expression of ABCG2/BRCP transporter gen and the aggressiveness of the TPC-1human cell-line of thyroid cancer. We have identified differential hyper-and under-expression of genes in PTC and FTC. 120 proteins have been identified by proteomic analysis.
• In vitro e in vivo evaluation of a an original thyroid chemotherapy.
- PGLA nanoparticles, loaded with an inhibitor of tyrosinkinase, recognize the neoplastic cells by a monoclonal antibody against EGFR.
DIABETES MELLITUS, METABOLIC SYNDROME, OBESITY, CARDIOMETABOLIC RISK
• Autoimmune Diabetes Mellitus.
- EU Research Consortium that has characterized the genetics, the immunology, the metabolic and the
clinical phenotype of LADA in 11 european countries
• Telemedicine and Intelligent Systems for the Therapeutical Optimization of Diabetes Mellitus.
- PREDIRCAM Project. Original technological platform of CIBER-BBN, previously validated; at present, a multicentric clinical trial is being developed in 3 Spanish University Hospitals. (Coordination, EDUAB-HSP)
- CONCEPTT: Continuous Glucose Monitoring (CGM) in Women with Type 1 Diabetes in Pregnancy Trial. First worldwide clinical trial to demonstrate the benefits of CGMS in diabetic pregnancy. EDUAB-HSP is a Member of the Steering Committee too (countries involved: Canada, Israel, Italy, Spain USA).
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PROGRAMMES
Bioengineering & Medical Imaging