Page 67 - CIBER-BBN2016-ENG

Most relevant scientific articles
• Huertas C.S., Carrascosa L.G., Bonnal S., Valcarcel J., Lechuga L.M. Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing. Biosensors and Bioelectronics. 2016;78:118-125.
• Soler M., Estévez M.-C., Moreno M.D.L., Cebolla A., Lechuga L.M. Label-free SPR detection of gluten peptides in urine for non-invasive celiac disease follow-up. Biosensors and Bioelectronics. 2016;79:158- 164.
• Maldonado J., González-Guerrero A.B., Domínguez C., Lechuga L.M. Label-free bimodal waveguide immunosensor for rapid diagnosis of bacterial infections in cirrhotic patients. Biosensors and Bioelectronics. 2016;85:310-316.
• Soler M., Estévez M.-C., Villar-Vázquez R., Casal J.I., Lechuga L.M. Label-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal cancer. Analytica Chimica Acta. 2016;930:31-38.
• González-Guerrero A.B., Maldonado J., Dante S., Grajales D., Lechuga L.M. Direct and label-free detection of the human growth hormone in urine by an ultrasensitive bimodal waveguide biosensor. Journal of Biophotonics. 2016.
Highlights
During 2016 we have progressed towards the consecution of integrated and multiplexed devices with interferometric nanophotonic biosensors and (nano)plasmonic biosensors. We have demonstrated their feasibility in several application fields, such as in the research line focused on the cellular pathways studies, which has been consolidated. In this regard, quantitative evaluation of alternatively spliced mRNA isoforms with label-free real-time sensing has been achieved. miRNA detection in biological media at exceptionally low limits of detection (aM range) has also been successfully demonstrated. These results have been summarized in three high impact factor publications. We keep focused also on other applications with clinical interest: detection of cancer biomarkers (i.e. autoantibodies, within project RETOS Colaboración COLONTEST); the specific detection of infectious diseases such as tuberculosis (EU-Project POCKET and additional collaborations); the detection of sepsis (EU-Project RAIS). In the environmental field, we have progressed in the detection of marine pollutants (EU-Project BRAAVOO).
New projects have been granted during 2016: two CIBER-BBN intramural projects (PcP-SENS and EYE-POC), dedicated to POC (Point-of-care) device development for the specific detection of Pneumocystis jirovecii Pneumonia and the Dry-eye disease, respectively. PcP-SENS has been awarded as Project of Excellence (PcP-SENS). Two new projects also granted focus on the development of integrated plasmonic prototypes: URINETEST (RETOS-Colaboración, RTC-2016-5452-1) for the monitoring of gluten-free diet by detecting gluten toxic peptides in urine, and PreDICT (RETOS Investigación, TEC2016-78515-R), towards de design and fabrication of an advanced multiplexed device for disease detection, progression and therapy follow- up in lung cancer. In the integrated nanophotonic biosensors research line we have been granted with
the NANOFOTOSENS project (Fundación Domingo Martínez) for the development of a novel ultrasensitive photonic nanosensor integrating a new class of porous materials (MOF, metal organic frameworks)
as specific receptors for the fast and specific detection of minute concentration of gas pollutants for environmental quality control.
BBN
Research Groups 67