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leaD reSearcher
Eritja Casadella, Ramon
Agencia Estatal Consejo Superior de Investigaciones Científicas
Instituto de Química Avanzada de Cataluña
C/ Jordi Girona, 18-26 08034 Barcelona
(+34) 93 400 61 45 [email protected] group Website
GROUP MEMBERS
Staff members: Aviñó Andrés, Ana María | Grijalvo Torrijo, Santiago
Associated members: Fábrega Clavería, Carmen | Fernandes Jorge, Andreia | Pérez Rentero, Sonia Contributors: Alagia, Adele
Main lines of research
• Development of new molecules which bind to DNA. Study of the interaction of drugs with DNA.
• Synthesis of oligonucleotides with non-natural nucleosides.
• Synthesis of modified RNA for the inhibition of gene expression by the RNA interference mechanism.
• Development of novel formulations for gene therapy and gene silencing.
• Synthesis and structural studies of quadruplex-forming oligonucleotides.
• Triple helix-forming oligonucleotides. Application of triplex affinity capture for the analysis of nucleic
acid sequences.
• Two-dimensional DNA crystals. Origami DNA.
• Synthesis of oligonucleotide-peptide conjugates.
• Use of oligonucleotides in biosensors. Surface functionalization with nucleic acid derivatives.
• Study of DNA repair processes with the aim of developing inhibitors that can be used to avoid
resistance to chemotherapy.
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PROGRAMMES
Nanomedicine