Page 51 - CIBERBBN-2015-eng

Most relevant scientific articles
Research groups
AVINO A., HUERTAS C.S., LECHUGA L.M., ERITJA R. Sensitive and label-free detection of miRNA-145 by triplex forma- tion. Analytical and Bioanalytical Chemistry. 2015;:1-9.
PéREZ-RENTERO S., GARGALLO R., GONZáLEZ C., ERITJA R. Modulation of the stability of i-motif structures using an acyclic threoninol cytidine derivative. RSC Advances. 2015;5(78):63278-63281.
FORNAGUERA C., GRIJALVO S., GALAN M., FUENTES-PANIA- GUA E., DE LA MATA F.J., GóMEZ R. et al. Novel non-viral gene delivery systems composed of carbosilane dendron func- tionalized nanoparticles prepared from nano-emulsions as non-viral carriers for antisense oligonucleotides. Inter- national Journal of Pharmaceutics. 2015;478(1):113-123.
Highlights
In collaboration with other CIBER-BBN (NANOBIO- CEL, NN-UMH) groups we have developed formu- lations for transfection of nucleic acids for gene therapy of ocular diseases. This research is funded by a Collaborative project (TERET). Moreover and in collaboration with the NBT-UAB and GOA-HSCSP groups of CIBER-BBN, our group has prepared nano- conjugates made of cytotoxic oligonucleotides and proteins directed against cancer stem cells that are able to effectively kill metastatic cells. This project is funded by the Foundation “La Marató de TV3” and by the Institutes of Health. In collaboration with the group of Nanomedicine of IBEC we have developed a method for immobilizing DNA probes based on [2 + 2] cycloaddition reactions catalyzed by Cu. An im- portant part of scientific activity has been focused on the evaluation of small RNA (siRNA) duplexes
GALAN T., PRIETO-SIMON B., ALVIRA M., ERITJA R., GOTZ G., BAUERLE P. ET AL. Label-free electrochemical DNA sensor using “click”-functionalized PEDOT electrodes. Biosensors and Bioelectronics. 2015;74:751-756.
AGIRRE M., OJEDA E., ZARATE J., PURAS G., GRIJALVO S., ERITJA R. ET AL. New Insights into Gene Delivery to Hu- man Neuronal Precursor NT2 Cells: A Comparative Study between Lipoplexes, Nioplexes, and Polyplexes. Molecular Pharmaceutics. 2015;12(11):4056-4066.
that are capable of silencing genes specifically. We have studied the introduction of small chemical modifications that increase the stability of siRNAs in serum and the ability to use nanostructured mate- rials (prepared by other groups CIBER-BBN) for the development of new formulations that increase the efficiency of transfection. In collaboration with the group of CIBER-BBN (ICN2-CSIC) we have studied thedetection of microRNA by SPR using capture probes with high efficiency which are able to form triple helices with the target miRNA. Finally, we have developed derivatives forming oligonucleotides guanine quadruplex having a great antiviral activity against HIV-1 virus and Hepatitis C. These results have been protected with a patent. Two Ph. D. stu- dents have passed their Ph.D. dissertions with hon- ours.
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas
Contact: Instituto de Química Avanzada de Cataluña · C/ Jordi Girona, 18-26. 08034 Barcelona
Tel.: 93 400 61 45 · E.mail: [email protected]
Web: http://www.iqac.csic.es/index.php?option=com_ogngrups&view=detall_grup&Itemid=95&cid=47&lang=es
CIBER-BBN I Annual report 2015 I 51