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Research groups
Nucleic Acid Chemistry Group
Programme: Nanomedicine
Lead Researcher: Eritja Casadellà, Ramon
Group members
STAFF MEMBERS: Aviñó Andrés, Ana María | Grijalvo Torrijo, Santiago.
ASSOCIATED MEMBERS: Fábrega Claveria, Carmen | Pérez Rentero, Sonia | Tintoré Gazulla, Maria. CONTRIBUTORS: Alagia, Adele.
Main lines of research
• Development of new molecules which bind to DNA. Study of the interaction of drugs with DNA.
• Synthesis of oligonucleotides with non-natural nucleosides.
• Synthesis of modified RNA for the inhibition of gene expression by the RNA interference mecha- nism.
• Development of novel formulations for gene ther- apy and gene silencing.
• Synthesis and structural studies of quadru- plex-forming oligonucleotides.
• Triple helix-forming oligonucleotides. Application of triplex affinity capture for the analysis of nucle- ic acid sequences.
• Two-dimensional DNA crystals. Origami DNA.
• Synthesis of oligonucleotide-peptide conjugates.
• Use of oligonucleotides in biosensors. Surface functionalization with nucleic acid derivatives.
• Study of DNA repair processes with the aim of developing inhibitors that can be used to avoid resistance to chemotherapy.
50 I Annual report 2015 I CIBER-BBN
