Page 40 - CIBERBBN-2015-eng

Research groups
Translational Research Group in Biomaterials
and Tissue Engineering
Programme: Biomaterials & Advanced Therapies Lead Researcher: Bellón Caneiro, Juan Manuel
Group members
STAFF MEMBERS: González Chamorro, Diana | Martínez-Alcocer Fuerte, Soraya | Pascual González, Ma Gemma. ASSOCIATED MEMBERS: Buján Varela, María Julia | García Honduvilla, Natalio.
CONTRIBUTORS: Pérez Köhler, Bárbara.
Main lines of research
• Biomaterials for the repair of abdominal wall defects. This research has the purpose of re- pairing damaged and/or missing tissues mainly located in the abdominal wall. Several types of biomaterials for clinical use have been used in this line as supports, new designs and modifica- tions thereof being developed. Different collagen bioprostheses as well as composites meshes and prosthetic materials with polymeric coatings that can reduce inflammation, accelerate healing process or prevent infection are currently being assayed. Tissue adhesives have recently been in- troduced in this line of research as a strategy for fixing prosthetic materials for hernia repair.
• Repair of skin defects. One of the alternatives for the repair of skin defects, especially in pa- tients with compromised healing (diabetics, tor- pid vascular ulcers and pressure ulcers) can be improved through tissue engineering strategies.
Essentially work is being conducted with two experimental models: muscle-derived stem cells for repairing excisional skin defects with encour- aging results, and the design of polymers for the controlled release of healing modulating drugs.
• Repair and vascular pathology. Research has been conducted within this line in healing/ reste- nosis, with special interest in the modulation thereof. The problem of arterial substitution by means of biomaterials for clinical use and cry- opreserved vessels has also been approached. Finally, tissue engineering techniques are used for the purpose of improving the viability of prosthetic materials through the creation of a cell coating and the incorporation of bioactive substances. Currently being working on venous insufficiency in pregnancy and in the search for predictive markers.
• Osteogenic regeneration. This research line
40 I Annual report 2015 I CIBER-BBN