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Main lines of research
• Design and synthesis of bioactive low molecular • Design and synthesis of gamma peptides with
Research groups
weight compounds and peptides.
• Dendrimers based on defined units of olidoethyl- ene glycol (OEG) as multifunctional systems for the creation of new biomaterials with application to drug delivery and tissue engineering (osteogen- esis).
• Drugs-polymer conjugates based on polyglutam- ic (PGA) or OEG dendrimers, as nanomedicine for the advanced colorectal cancer treatment. Study of the use of these platforms on monotherapy and combined therapy.
• Multiple ligands as chemical tools to study var- ious biological processes, for example: G pro- tein-coupled receptors (GPCRs) oligomerization.
• Design and synthesis of a bicomponent thermor- eversible hydrogel platform which combines the bioactive peptide dendrimer decorated hyaluronic acid with the thermoresponsive hyaluronic acid for developing scaffolds for tissue engineering with application to regenerative medicine (bone and cartilage regeneration).
• Development of protein drug delivery systems (PEGylation, peptide functionalized nanovesicles) for substitutive therapy (ie: Fabry disease).
capacity to cross biological barriers, such as the cytoplasmatic membrane of eukaryotic cells and parasites (Leishmania) and the blood brain barrier (BBB).
• Development of new target peptides for colorectal and triple negative breast cancer tissues.
• Vectorized multicomponent nanoparticles as drug delivery systems and modulators of pharma- cokinetic properties.
• Multimodal imaging agents (SPECT, OI, CT and MRI). Nanoparticles for imaging diagnostic appli- cations.
• Surface engineering for controlling cell prolifera- tion on diverse materials.
• Development of solid phase methodology to syn- thesize biomolecules and other compounds.
• Bionanotechnologies as new strategy to save compounds that failed on clinical or preclinical phases.
Institution: Universitat de Barcelona · Contact: Gran Vía de las Corts Catalanes, 585, Centre Ciutat, Plaça Universitat, Edifici Historic, Planta 1a 08007 Barcelona · E.mail: [email protected] Website: http://www.irbbarcelona.org/index.php/en/research/programmes/chemistry-and-molecular- pharmacology/combinatorial-chemistry-for-the-discovery-of-new-compounds/people/fernando-albericio
CIBER-BBN I Annual report 2015 I 35