Page 91 - CIBER-BBN2016-ENG

Most relevant scientific articles
• Prieto J., León M., Ponsoda X., Sendra R., Bort R., Ferrer-Lorente R. et al. Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming. Nature Communications. 2016;7.
• Tekeli I., Aujard I., Trepat X., Jullien L., Raya A., Zalvidea D. Long-term in vivo single-cell lineage tracing of deep structures using three-photon activation. Light: Science and Applications. 2016;5(6).
• Capellera-García S., Pulecio J., Dhulipala K., Siva K., Rayon-Estrada V., Singbrant S. et al. Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion. Cell Reports. 2016;15(11):2550-2562.
• Vassena R., Heindryckx B., Peco R., Pennings G., Raya A., Sermon K. et al. Genome engineering through CRISPR/Cas9 technology in the human germline and pluripotent stem cells. Human Reproduction Update. 2016;22(4):411-419.
• Pulecio J., Alejo-Valle O., Capellera-García S., Vitaloni M., Rio P., Mejía-Ramírez E. et al. Direct Conversion of Fibroblasts to Megakaryocyte Progenitors. Cell Reports. 2016;17(3):671-683.
Highlights
During 2016, the group Centre of Regenerative Medicine in Barcelona has focused its research activities
on the development of biomedical applications of cell reprogramming. These activities have pursued the design of strategies of regenerative medicine in the context of cardiac disease, with the ultimate goal of generating tissue engineering constructs useful for treating end-stage heart failure.
The collaborative and ambitious Integrated Project of Excellence (PIE1400061) coordinated by our group, which compromises a consortium of 12 research groups members of 4 different CIBER, has allowed to develop the model of neuronal dysfunction in Lafora disease based on patient-specific induced pluripotent stem cells and to progress in the search for molecular links between diabetes and neurodegenerative disorders.
During this year, among the most relevant milestones of our group, it is worth to highlight our study regarding the possibility to convert skin cells into megakaryocytes able to produce platelets. An achievement with a great impact on the media.
The intense activity in the group work areas is reflected in numerous publications in indexed high impact journals, 3 PhD theses defended and new funds obtained from the competitive calls:
• 20153430. Investigating genetic and mechanistic interactors in Familial Cardiomyopathy through advanced disease (FUNDACIÓ LA MARATÓ DE TV3).
• COMRDI15-1-0013. Teràpies Avançades a Catalunya. ADVANCECAT. Comunitat NEXTHEALTH, BIOCAT (BIOCAT, FEDER, GENCAT).
• RD12/0019/0019. RETICS- Red de Terapia Celular (ISCIII, FEDER).
• SAF2015-71863-REDT. Estudio de las interacciones genéticas y mecanísticas en la miocardiopatía
familiar mediante modelaje avanzado de la enfermedad (MINECO).
• SAF2015-69706-R. Diseño de estrategias para controlar la proliferación, diferenciación y maduración de
cardiomiocitos humano (MINECO, FEDER).
In addition, in 2016 our group has started 2 intramural projects, in one of them as coordinator.
BBN
Research Groups 91