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systems obtained with bio technologic products.
• Nanocarriers for pulmonary administration: the aim of this work line is the design, optimization
and characterization of vehicles in the nanometric range that are intended to be administered pulmonary. These systems present many advantages, such as mucoadhesion, biodegradability, no first pass effect hence the possibility to reduce the dose, good tolerability, deep lung deposition of the drug and sustained release of the API thus longer dosing interval. These systems are applied for the nanoformulation of DNA, peptide, antineoplasics and antibiotics.
Most relevant scientific articles
• Ojeda E., Puras G., Agirre M., Zarate J., Grijalvo S., Eritja R. et al. The influence of the polar head- group of synthetic cationic lipids on the transfection efficiency mediated by niosomes in rat retina and brain. Biomaterials. 2016;77:267-279.
• Hernando S., Gartziandia O., Herrán E., Pedraz J.L., Igartua M., Hernández R.M.. Advances in nanomedicine for the treatment of Alzheimer’s and Parkinson’s diseases. Nanomedicine. 2016;11(10):1267-1285.
• Ojeda E., Puras G., Agirre M., Zarate J., Grijalvo S., Eritja R. et al. The role of helper lipids in the intracellular disposition and transfection efficiency of niosome formulations for gene delivery to retinal pigment epithelial cells. International Journal of Pharmaceutics. 2016;503(1-2):115-126.
• Gartziandia O., Egusquiaguirre S.P., Bianco J., Pedraz J.L., Igartua M., Hernández R.M. et al. Nanoparticle transport across in vitro olfactory cell monolayers. International Journal of Pharmaceutics. 2016;499(1-2):81-89.
• García-Orue I., Gainza G., Gutiérrez F.B., Aguirre J.J., Evora C., Pedraz J.L. et al. Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications. International Journal of Pharmaceutics. 2016.
Highlights
• Boosting the line of pulmonary formulations through Feder Funds from the NANBIOSIS Platform with the purchase of a cascade impactor system.
• Eleven publications of indexed magazines.
• Four thesis defended in the Drug Delivery, Tissue Engineering and Gene Therapy.
• A total of five national projects, of which two are Retos-Colaboración.
BBN
Research Groups 85