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the creation of a cell coating and the incorporation of bioactive substances. Currently being working on
venous insufficiency in pregnancy and in the search for predictive markers.
• Osteogenic regeneration. This research line was introduced in our department as a result of
collaboration with the group COFIBIC. Regeneration of critical bone defects using tissue engineering techniques, by implanting osteogenic constructs, and aspects of biocompatibility bone substitutes in different experimental models, are currently in progress.
Most relevant scientific articles
• Pascual G, Sotomayor S, Rodríguez M, Pérez-Köhler B, Kühnhardt A, Fernández-Gutiérrez M et al. Cytotoxicity of Cyanoacrylate-Based Tissue Adhesives and Short-Term Preclinical In Vivo Biocompatibility in Abdominal Hernia Repair. PloS one. 2016;11(6):e0157920.
• Calvo B., Pascual G., Pena E., Pérez-Kholer B., Rodríguez M., Bellón J.M.. Biomechanical and morphological study of a new elastic mesh (Ciberlastic) to repair abdominal wall defects. Journal of the Mechanical Behavior of Biomedical Materials. 2016;59:366-378.
• Fernández-Gutiérrez M., Rodríguez-Mancheno M., Pérez-Kohler B., Pascual G., Bellón J.M., Román J.S.. Structural Analysis and Application of n-Alkyl Cyanoacrylate Surgical Adhesives to the Fixation of Meshes for Hernia Repair. Macromolecular Bioscience. 2016;16(12):1803-1814.
• Sotomayor S., Pascual G., Blanc-Guillemaud V., Mesa-Ciller C., García-Honduvilla N., Cifuentes A. et al. Effects of a novel NADPH oxidase inhibitor (S42909) on wound healing in an experimental ischemic excisional skin model. Experimental Dermatology. 2016.
• Vila M., García A., Girotti A., Alonso M., Rodríguez-Cabello J.C., González-Vázquez A. et al. 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine. Acta Biomaterialia. 2016;45:349-356.
Highlights
In connection with our research line in biomaterials for the repair of abdominal wall defects, the second year of the national project “R&D Excellence Projects” SAF2014-55022-P, “Bioassay of a new cyanoacrylate for internal use (n-octyl/CIAH) of implanted prosthetic materials for the repair of hernia defects” CIANOMESH”, has been successfully carried out. In addition, two transfer contracts (Art. 83) have been signed with the company Medtronic in the field of prosthetic infection. The productivity of the line has been significant
with eight published articles (four Q1). A number of invited papers and presentations have been presented
at the 10th World Biomaterials Congress in Montreal, 51st Congress of the ESSR held in Prague and 38th International Congress of the EHS in Rotterdam.
Regarding our line of research in the repair of skin defects, in 2016 an article in Experimental Dermatology (Q1) has been published, derived from the results obtained from an Art. 83 signed with SERVIER. An important contract has been signed in the area of pharmacological healing, with the company Genzyme Corporation. A communication was presented at the 32nd ECTRIMS Congress.
Within the line of repair and vascular pathology, the last year of the National Research Project “Venous insufficiency in pregnancy: search for predictive markers” has been successfully completed, funded by the Instituto de Salud Carlos III (PI13 / 01513). Several papers have been presented at the XXXII LIAC Meeting on Vascular Research, held in Italy, 9th European Elastin Meeting, Germany and 2016 American Society for Matrix Biology (ASMB), held in the USA.
Regarding the line of osteogenic regeneration, the activity of the group has been focused on the SCAFFBONE intramural project. An article in Acta Biomaterialia (Q1) has been published and several papers have been presented at the III Iberoamerican Congress of Histology, held in Mexico and ASMB.
BBN
Research Groups 43