Page 113 - CIBER-BBN2016-ENG

Most relevant scientific articles
• Magana J.R., Homs M., Solans C., Obiols-Rabasa M., Salonen L.M., Rodríguez-Abreu C. Self-Assembly and Formation of Chromonic Liquid Crystals from the Dyes Quinaldine Red Acetate and Pyronin y. Journal of Physical Chemistry B. 2016;120(1):250-258.
• Fornaguera C., Caldero G., Solans C. Electrolytes as a tuning parameter to control nano-emulsion and nanoparticle size. RSC Advances. 2016;6(63):58203-58211.
• Magana J.R., Kolen’Ko Y.V., Deepak F.L., Solans C., Shrestha R.G., Hill J.P. et al. From Chromonic Self-Assembly to Hollow Carbon Nanofibers: Efficient Materials in Supercapacitor and Vapor-Sensing Applications. ACS Applied Materials and Interfaces. 2016;8(45):31231-31238.
• Fornaguera C., Feiner-Gracia N., Caldero G., García-Celma M.J., Solans C. PLGA nanoparticles from nano-emulsion templating as imaging agents: Versatile technology to obtain nanoparticles loaded with fluorescent dyes. Colloids and Surfaces B: Biointerfaces. 2016;147:201-209.
• Caldero G., Montes R., Llinas M., García-Celma M.J., Porras M., Solans C. Studies on the formation of polymeric nano-emulsions obtained via low-energy emulsification and their use as templates for drug delivery nanoparticle dispersions. Colloids and Surfaces B: Biointerfaces. 2016;145:922-931.
Highlights
The research activites have been developed mainly in the frame of the intramural Project “Novel nanocarriers as delivery systems across the Blood-Brain barrier” (Nano3B) which objective is the design
of new multifunctional polymeric nanoparticles targeting the blood-brain barrier (BBB) for the combined therapy of a neurodegenerative disease, X-linked adrenoleukodystrophy (X-ALD). PLGA nanoparticles
with tunable characteristics, sizes below 100nm, high kinetic stability, encapsulating specific drugs
have been prepared using non-toxic materials and low-energy methods. The nanoparticles have been functionalized with monoclonal antibodies and peptides specific to cross the BBB. The determination of drug concentration in tissues of murine models after treatment with the nanoparticles has shown that they are appropriate for the intended application. In addition, the group has developed research in the frame of two intramural projects started in 2016: “Novel functionalized contact lenses with antiantimicrobial properties for the prevention of keratitis” (Functiolenses) y “Non-invasive blood-brain barrier opening by focused ultrasounds for the selective delivery of therapeutic nanocarriers against glioma” (Glio-Select). Moreover, the group has carried research in the frame of two I+D+I Spanish-funded projects “Design and applications of novel biocompatible micro/nanogels obtained by advanced condensation methods” (CTQ2014-52687-C3-1-P y “Strategies for preparation and stabilization of water-in-water emulsions
for innovative pharmaceutical and food applications” CTQ2016-80645-R) and one funded by the EU “Biopolymer-Based Food Delivery Systems” (Bibafoods). The most important outcomes of the results obtained are reflected in 14 indexed publications and 2 book chapters, as well as in the presentation of 10 oral (1 Plenary Lecture and 1 Invited Lecture) communications and 9 poster presentations in national and international conferences. 3 PhD thesis and 2 Master theses have been presented. Other activities include the organization of FORMULA VIII Conference (Barcelona July 4-7, 2016) and the edition of an issue of “Current Opinion in Colloid and Interface Science” on Emulsions and Microemulsions.
BBN
Research Groups 113