Page 103 - CIBER-BBN2016-ENG

Engineering). The polymer systems offer wide spectra of formulations with hydrophobic or hydrophilic character, which allows the preparation of 3D scaffolds to be applied in regeneration of bone tissue, epidermal or connective tissues, with specific properties. Several patents have been registered and are on transfer processes to several companies of the biomedical device sector.
• Application of supercritical technologies for the preparation of porous systems. Based on the application of carbonic anhydride in supercritical conditions for the preparation of clean bioactive polymer systems and composites for different applications. The technology allows the development of systems for Tissue Engineering and drug delivery systems. Also, the preparation of systems with bioactive compounds sensitive to the pH or temperature are considered in this section.
Most relevant scientific articles
• Palao-Suay R., Aguilar M.R., Parra-Ruiz F.J., Maji S., Hoogenboom R., Rohner N.A. et al. α-TOS-based RAFT block copolymers and their NPs for the treatment of cancer. Polymer Chemistry. 2016;7(4):838-850.
• Palao-Suay R., Gómez-Mascaraque L.G., Aguilar M.R., Vázquez-Lasa B., Román J.S. Self-assembling polymer systems for advanced treatment of cancer and inflammation. Progress in Polymer Science. 2016;53:207-248.
• Martín-Saldana S., Palao-Suay R., Trinidad A., Aguilar M.R., Ramírez-Camacho R., San Román J. Otoprotective properties of 6α-methylprednisolone-loaded nanoparticles against cisplatin: In vitro and in vivo correlation. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016;12(4):965-976.
• Martín-del-Campo M., Rosales-Ibánez R., Alvarado K., Sampedro J.G., García-Sepúlveda C.A., Deb S. et al. Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce: In vivo bone regeneration in critical sized defects. Biomaterials Science. 2016;4(11):1596-1604.
• Fernández-Gutiérrez M., Rodríguez-Mancheno M., Pérez-Kohler B., Pascual G., Bellón J.M., Román J.S. Structural Analysis and Application of n-Alkyl Cyanoacrylate Surgical Adhesives to the Fixation of Meshes for Hernia Repair. Macromolecular Bioscience. 2016;16(12):1803-1814.
Highlights
Respect to the development of systems and products, it is worth noting that the team has designed and fabricated biodegradable membranes to stimulate cartilage repair, project that has been developed in collaboration with the company BIOIBERICA and at moment, the company has to make the decision to present an international patent. Bioactive nanoparticles of low toxicity based on mitocans (agents with activity on mitochondria) have been developed with good results for cancer treatment. This system, fabricated by molecular design in physiological conditions, has been loaded with corticoids (methyl-prednisolone, dexamethasone) and applied to inhibit cis-platin effects associated to chemotherapy which produced deafness in the patient. The application of a nanoparticles suspension in the inner ear of animals gave excellent results to inhibit cis-platin locally. This system has attracted the attention of a pharmaceutical company that is interested in its application and commercialization. These projects allowed presenting 3 doctoral theses with maximum qualification in Spanish universities, and with contributions not only relevant in the academic field, but also with important implications of transfer as novel products and processes to the productive sector. One thesis was presented under confidentiality and the company concerned is adapting
its production in Germany. Likewise, the nanoparticle system loaded with dexamethasone, developed in collaboration with the ORL team of Hospital Puerta de Hierro de Madrid, will be transferred shortly to the company Beacon Biomedicine by means of a transfer cooperation agreement with CIBER-BBN.
BBN
Research Groups 103