Page 89 - CIBERBBN-2015-eng

Research groups
Most relevant scientific articles
MARTORELL L., CORRALES I., RAMIREZ L., PARRA R., RAYA A., BARQUINERO J. ET AL. Molecular characterization of ten F8 splicing mutations in RNA isolated from patient’s leuco- cytes: Assessment of in silico prediction tools accuracy. Haemophilia. 2015;21(2):249-257.
NOTARI M., PULECIO J., RAYA A. Update on the pathogenic implications and clinical potential of microRNAs in cardi- ac disease. BioMed Research International. 2015;2015.
GALVEZ-MONTON C., FERNáNDEZ-FIGUERAS M.T., MARTI M., SOLER-BOTIJA C., ROURA S., PEREA-GIL I. ET AL. Neoinner- vation and neovascularization of acellular pericardial-de- rived scaffolds in myocardial infarcts. Stem Cell Research and Therapy. 2015;6(1).
Highlights
During 2015, the research activities of our group have centered on the development of biomedical applications of cell reprogramming. These activities have pursued the design of strategies of regenera- tive medicine in the context of cardiac disease, with the ultimate goal of generating tissue engineering constructs (myocardial patches and grafts) useful for treating end-stage heart failure. For this purpose, we have developed protocols for the directed differ- entiation of human pluripotent stem cells toward heart muscle cells, and for their 3D culture in hydro- gels and/or porous scaffolds using continuous per- fusion bioreactors. Within these culture systems, we have tested the positive effect of electrical and me- chanical stimulation on the functional maturation of cardiomyocytes. In addition to this, we have devel-
CANALS I., SORIANO J., ORLANDI J.G., TORRENT R., RICHAUD-PATIN Y., JIMéNEZ-DELGADO S. ET AL. Activity and high-order effective connectivity alterations in sanfilippo C patient-specific neuronal networks. Stem Cell Reports. 2015;5(4):546-557.
FERNáNDEZ-SANTIAGO R., CARBALLO-CARBAJAL I., CASTEL- LANO G., TORRENT R., RICHAUD Y., SáNCHEZ-DANES A. ET AL. Aberrant epigenome in iPSC-derived dopaminergic neu- rons from Parkinson’s disease patients. EMBO Molecular Medicine. 2015.
oped a variety of human disease models based on patient-specific induced pluripotent stem (iPS) cells. Specifically, we have developed and further validat- ed experimental models of neuronal dysfunction in Sanfilippo C disease, of pre-mRNA processing in hepatocytes derived from hemophilia patients, and of the epigenetic alterations present in dopaminer- gic neurons derived from Parkinson’s disease pa- tients. This last experimental model has also been the basis to search for molecular links between dia- betes and neurodegenerative diseases, a large-scale project involving 12 research groups from 4 different CIBERs, funded as an Integrated Project of Excel- lence, and coordinated by our group.
Institution: Centro de Medicina Regenerativa de Barcelona · Contact: Dr. Aiguader 88, 7a planta. 08003 Barcelona · E.mail: [email protected] · Web: http://www.cmrb.eu
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