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Research groups
Micro and Nano Technologies, Biomaterials
and Cells Research Group
Programme: Nanomedicine / Biomaterials & Advanced Therapies Lead Researcher: Pedraz Muñoz, José Luis
Group members
STAFF MEMBERS: Ciriza Astrain, Jesús | Losada Narvaez, Ángela.
ASSOCIATED MEMBERS: Acarregui Garalde, Argia | Esquisabel Alegría, Amaia | Hernández Martín, Rosa María | Igartua Olaechea, Manoli | Orive Arroyo, Gorka | Puras Ochoa, Gustavo | Sáenz del Burgo Martínez, Laura | Salvador Martínez, Aiala | Santos Vizcaíno, Edorta | Zárate Sesma, Jon.
CONTRIBUTORS: Agirre Díez, Mireia | Egusquiaguirre Martín, Susana Patricia | Gartziandia López de Goikoetxea, Oihane | Herrán Martínez, Enara | Moreno Sastre, María.
Main lines of research
• Microencapsulation of alive cells: Design and optimization of polymeric systems for immo- bilization of cells with therapeutic activity. This system provides protection to cells against the host’s immune response due to its technological design, and at the same time, it turns into a con- trolled release pharmaceutical system.
• Micro and nano-particles as vaccine adminis- tration systems of peptides and proteins: Prom- ising results obtained by our research group support the use of these drug (antigen) carrier systems to develop vaccines, as demonstrated by the results after their administration by differ- ent routes in laboratory animals (mice and mon- keys), inducing a sustained and strong immune response.
• Non viral vectors for gene therapy purposes: De- sign and optimization of non-viral vectors based on lipidic and polymeric nanoparticles to trans- fect eukaryotic cells with therapeutic genes.
• Development of modified release formulations: Development and optimization of drug delivery systems based on new polymers to obtain a sustained release profile of drugs.
• Pharmacocinetic and biopharmaceutical evalu- ation of modified drug delivery and therapeutic systems obtained with bio technologic products.
• Nanocarriers for pulmonary administration: the aim of this work line is the design, optimization and characterization of vehicles in the nanomet- ric range that are intended to be administered pulmonary. These systems present many advan-
82 I Annual report 2015 I CIBER-BBN