Page 66 - CIBERBBN-2015-eng

Research groups
Endocrinology and Diabetes Research Group
Programme: Bioengineering & Medical Image / Nanomedicine Lead Researcher: Leiva Hidalgo, Alberto
Group members
STAFF MEMBERS: Bell Ramírez, Olga Lidia | Mato Matute, Ma Eugenia. ASSOCIATED MEMBERS: Chico Ballestero, Ana Isabel | Corcoy Pla, Rosa. CONTRIBUTORS: Cubero Marcos, José María | González Blanco, Cintia.
Main lines of research
THYROID CANCER
• Markers of prognostic prediction: Implication of 21 genes in CDT. Development of data base, and a pri- vate collection of serum and tissue bank of epithe- lial thyroid cancer (more of 200 cases). We found he relationship between the expression of ABCG2/ BRCP transporter gen and the aggressiveness of the TPC-1human cell-line of thyroid cancer. We have identified differential hyper-and under-ex- pression of genes in PTC and FTC. 120 proteins have been identified by proteomic analysis.
• In vitro e in vivo evaluation of a an original thyroid chemotherapy. PGLA nanoparticles, loaded with an inhibitor of tyrosinkinase, recognize the neoplastic cells by a monoclonal antibody against EGFR.
DIABETES MELLITUS, METABOLIC SYNDROME, OBESITY, CARDIOMETABOLIC RISK.
• Diabetes Mellitus Autoinmune: Autoimmune Dia- betes Mellitus. EU Research Consortium that has
•
characterized the genetics, the immunology, the metabolic and the clinical phenotype of LADA in 11 european countries
Telemedicine and Intelligent Systems for the Ther- apeutical Optimization of Diabetes Mellitus: - PRE- DIRCAM Project. Original technological platform of CIBER-BBN, previously validated; at present, a mul- ticentric clinical trial is being developed in 3 Spanish University Hospitals. (Coordination, EDUAB-HSP) - CONCEPTT: Continuous Glucose Monitoring (CGM) in Women with Type 1 Diabetes in Pregnancy Trial. First worldwide clinical trial to demonstrate the ben- efits of CGMS in diabetic pregnancy. EDUAB-HSP is a Member of the Steering Committee too (countries involved: Canada, Israel, Italy, Spain USA). - DALI Project: Lifestyle intervention in the prevention of Gestational Diabetes (GDM). It is a EU Research Pro- ject (7th Framework). - Telemedicine and Intelligent Systems for Therapeutic Optimization of Diabetes
66 I Annual report 2015 I CIBER-BBN