Page 57 - CIBER-BBN2016-ENG

Most relevant scientific articles
• Pena-González C.E., García-Broncano P., Ottaviani M.F., Cangiotti M., Fattori A., Hierro-Oliva M. et al. Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization, and Antiviral Activity. Chemistry - A European Journal. 2016;22(9):2987-2999.
• Cena-Díez R., Vacas-Córdoba E., García-Broncano P., de la Mata F.J., Gómez R., Maly M. et al. Prevention of vaginal and rectal herpes simplex virus type 2 transmission in mice: Mechanism of antiviral action. International Journal of Nanomedicine. 2016;11:2147-2162.
• Bravo-Osuna I., Vicario-De-La-Torre M., Andrés-Guerrero V., Sánchez-Nieves J., Guzmán-Navarro M., De La Mata F.J. et al. Novel water-soluble mucoadhesive carbosilane dendrimers for ocular administration. Molecular Pharmaceutics. 2016;13(9):2966-2976.
• Sepúlveda-Crespo D., Vacas-Córdoba E., Márquez-Miranda V., Araya-Durán I., Gómez R., Mata F.J.D.L. et al. Effect of Several HIV Antigens Simultaneously Loaded with G2-NN16 Carbosilane Dendrimer in the Cell Uptake and Functionality of Human Dendritic Cells. Bioconjugate Chemistry. 2016;27(12):2844- 2849.
• Perise-Barrios A.J., Fuentes-Paniagua E., Sánchez-Nieves J., Serramia M.J., Alonso E., Reguera R.M. et al. Improved Efficiency of Ibuprofen by Cationic Carbosilane Dendritic Conjugates. Molecular Pharmaceutics. 2016;13(10):3427-3438.
Highlights
The activity of the group during 2016 has been centered in the development of new dendritic nanosystems in two directions: (i) design of improved non-viral vectors for gene therapy in HIV and cancer and (ii) design of HIV antiviral, antibacterial, anticancer and antineurodegenerative agents, funded by european (IRSES) and national (CTQ2014-54004-P, MINECO and PIE14/00061, INTERCIBER) projects. The research carried
out, focused in the search of a new therapeutic approach based on the use of anionic dendrimer, gold and PLGA nanoparticles towards not only the HIV treatment but also other viruses like Herpes or Hepatitis C. Also, we were working in the use of cationic dendritic systems against bacteria and parasites in the search of structure/activity relationships. In the other hand, new cationic dendritic systems have been evaluated in ocular administration, as well as metallodendrimers based on ruthenium as new anticancer agents. Finally, cationic carbosilane dendrimers with and without the binding of chemical chaperones have been prepared for future applications in neurodegenerative diseases.
Results of the research has led to 17 publications. The group has continued intensifying its activities related to technology transfer applying for a national Spanish patent based on the preparation of carbosilane dendrons functionalized with fatty acid at the focal point for the formation of micelles and their uses.
In addition, a PCT extension of a national patent on the use of metallic nanoparticles stabilized with carbosilane dendrons for biomedical applications was carried out. In this sense, in December of 2016, we obtained the first prize in the 1o call for the best national patent of the University of Alcalá.
BBN
Research Groups 57