Page 117 - CIBERBBN-2015-eng

Research groups
Most relevant scientific articles
CIFUENTES S.C., GAVILAN R., LIEBLICH M., BENAVENTE R., GONZáLEZ-CARRASCO J.L. In vitro degradation of biode- gradable polylactic acid/magnesium composites: Rele- vance of Mg particle shape. Acta Biomaterialia. 2015.
BLOOM D.C., FELLER J., MCANANY P., VILABOA N., VOELLMY R. Replication-competent controlled herpes simplex virus. Journal of Virology. 2015;89(20):10668-10679.
VOELLMY R., BLOOM D.C., VILABOA N. A novel approach for addressing diseases not yielding to effective vaccination? Immunization by replication-competent controlled virus. Expert Review of Vaccines. 2015;14(5):637-651.
Highlights
The group of Bone Physiopathology and Biomate- rials has performed a thorough characterization of several modifications of polymers, stainless steel and ferritic alloys, including the study of their deg- radability, nanomechanical properties and biocom- patibility. The group has progressed in the develop- ment of gene switches for the spatial and temporal regulation of therapeutic transgenes. The switches have been adapted to drive the expression of viral proteins for generating replication- competent con- trolled herpes simplex virus as well as of osteogen- ic and angiogenic growth factors. These molecular tools are being targeted for use in several biomed-
FRUTOS E., GONZáLEZ-CARRASCO J.L. Dynamic nanome- chanical properties of novel Si-rich intermetallic coatings growth on a medical 316 LVM steel by hot dipping in a hypereutectic Al-25Si alloy. Journal of the Mechanical Be- havior of Biomedical Materials. 2015;46:93-103.
VALLES G., BENSIAMAR F., CRESPO L., ARRUEBO M., VILABOA N., SALDANA L. Topographical cues regulate the cross- talk between MSCs and macrophages. Biomaterials. 2015;37:124-133.
ical applications such as vaccination, oncolytic therapy or regenerative medicine. Furthermore, we examined whether surface topographical features can regulate the paracrine interactions that mesen- chymal stem cells establish with the mononuclear phagocyte system. The clinical scientists of the group have continued their participation in clinical trials for therapeutic interventions in bone-related diseases. The group funded its activities by means of grants from MINECO, ISCIII and research con- tracts with the industry.
Institution: Servicio Madrileño de Salud · Contact: Hospital La Paz · Paseo de la Castellana, 261 28046 Madrid · Tel.: 91 207 10 34 · E.mail: [email protected]
Web: http://www.idipaz.es/PaginaDinamica.aspx?IdPag=300&Lang=EN
CIBER-BBN I Annual report 2015 I 117