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Research groups
Most relevant scientific articles
FORNAGUERA C., GRIJALVO S., GALAN M., FUENTES-PANIAGUA E., DE LA MATA F.J., GóMEZ R. ET AL. Novel non-viral gene delivery systems composed of carbosilane dendron func- tionalized nanoparticles prepared from nano-emulsions as non-viral carriers for antisense oligonucleotides. Interna- tional Journal of Pharmaceutics. 2015;478(1):113-123.
VILANOVA N., SOLANS C. Vitamin A Palmitate-β-cyclodex- trin inclusion complexes: Characterization, protection and emulsification properties. Food Chemistry. 2015;175:529- 535.
FORNAGUERA C, CALDERó G, MITJANS M, VINARDELL MP, SOLANS C, VAUTHIER C. Interactions of PLGA nanoparticles with blood components: protein adsorption, coagulation,
Highlights
The research activities have been mainly performed in the frame of CIBER-BBN intramural project “Novel nanocarriers as delivery systems across the Blood- Brain barrier” (Nano3B). The main objective of the project was the design, characterization and func- tionalization of advanced multifunctional polymeric nanoparticles for the therapy of neurodegenerative diseases. Nanoparticles, with sizes below 100 nm, have been obtained by nano-emulsion templating using low-energy methods. This technology, devel- oped in our group, allows nanoparticle size control and high drug entrapment efficiency using biocom- patible components. Moreover, it can be performed under mild processing conditions, requires simple equipment and it is easily scalable. The nanoparti- cles have been functionalized with self-penetrating peptides and monoclonal antibodies for the specific blood-brain barrier (BBB) targeting and encapsulat- ed with fluorescents agents and specific drugs to treat X-linked adrenoleukodystrophy (X-ALD) dis- ease. In addition, in vitro and in vivo evaluation of the drug–loaded functionalized nanoparticles has
activation of the complement system and hemolysis studies.Nanoscale. 2015;7(14):6045-58.
FORNAGUERA C., DOLS-PéREZ A., CALDERO G., GARCíA-CEL- MA M.J., CAMARASA J., SOLANS C. PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood-brain barrier. Journal of Controlled Release. 2015;211:134-143.
FORNAGUERA C., FEINER-GRACIA N., CALDERO G., GARCíA-CEL- MA M.J., SOLANS C. Galantamine-loaded PLGA nanoparti- cles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseas- es. Nanoscale. 2015;7(28):12076-12084.
been performed. The results have showed that the designed nanoparticles are appropriate for the in- tended application. The group has also performed research activities in the frame of the following projects: “Multifunctional nanotechnology for se- lective detection and treatment of cancer” (FP7- NMP-2010-LARGE-4; C-NMP/0878) finalized in June 2015, “Studies on amphiphile self-assembly processes and technologies for eco-friendly and biocompatible applications” (CTQ2011-29336-C03) and “Formation of Pickering emulsions by low-en- ergy methods for the preparation of new porous nanostructured materials” (CTQ2011- 23842) both finalized in December 2015. The most important outcomes are reflected in 13 indexed publications, as well as in the presentation of 12 oral and 13 poster presentations in national and international conferences. Moreover, 3 PhD thesis and 4 Master thesis have been presented.
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas
Contact: Instituto de Química Avanzada de Cataluña · C/ Jordi Girona, 18-26. 08034 Barcelona Tel.: 93 400 61 59 · E.mail: [email protected] · Website: http://www.iqac.csic.es/qci
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